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KMID : 0613320090150010007
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Journal of the Korean Bone and Joint Tumor Soceity
2009 Volume.15 No. 1 p.7 ~ p.12
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TLE1: A New Molecular Target of Synovial Sarcoma
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Cho Eun-Yoon
Kim Dong-Wook
Seo Sung-Wook
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Abstract
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Purpose: This study was aimed to assess TLE1 as a target molecule of synovial sarcoma.
Method: We obtained tissue samples and clinical data from 36 patients who were diagnosed and treated for synovial sarcoma in our hospital. Immunohistochemical staining was performed to detect the expression of TLE1 in synovial sarcoma and normal tissues such as fat, skeletal muscle, peripheral nerve, vascular endothelium, and epithelium. Univariate survival analysis was performed to find whether overexpression of TLE1 is correlated to poor prognosis.
Results: TLE1 was expressed in 35 (97%) cases (grade 1 was 5 cases, grade 2 was 28 cases, grade 3 was 2 cases.). Normal tissues from mesenchymal origin did not express TLE1. However, epithelial and endothelial cells showed weak expression (grade 1) of TLE1. The level of TLE1 expression did not have any prognostic significance according to univariate survival analysis.
Conclusion: TLE1 may be a new molecular target of synovial sarcoma that differentiates synovial sarcoma from normal mesenchymal cells
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KEYWORD
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TLE1, Synovial sarcoma, Molecular target
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